Instructions from PDF of HTC Droid Eris (running Android):
Contact with the antenna area may impair call quality and cause your device to operate at a higher power level than needed. Avoiding contact with the antenna area when the phone is IN USE optimizes the antenna performance
…and remove the device from your pants’ pocket before sitting down. It is also recommended that you store the device in a protective case…
Antennagate is contagious.